Medical Physics
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Training artificial intelligence with artificial X-rays
July 6, 2018 by
Jessica Macinnis, University of
Toronto
On the left of each quadrant is a real X-ray image of
a patient's chest and beside it, the syntheisized X-ray formulated by the
DCGAN. Under the X-ray images are corresponding heatmaps, which is how the
machine learning system sees the images. Credit: Hojjat Salehinejad/MIMLab
Artificial intelligence (AI) holds
real potential for improving both the speed and accuracy of medical
diagnostics. But before clinicians can harness the power of AI to identify
conditions in images such as X-rays, they have to 'teach' the algorithms what
to look for.
Identifying rare pathologies in
medical images has presented a persistent challenge for researchers, because of
the scarcity of images that can be used to train AI systems in a supervised
learning setting.
Professor Shahrokh Valaee and his
team have designed a new approach: using machine learning to create computer
generated X-rays to augment AI training sets.
"In a sense, we are using
machine learning to do machine learning," says Valaee, a professor in The
Edward S. Rogers Sr. Department of Electrical & Computer Engineering (ECE)
at the University of Toronto. "We are creating simulated X-rays that
reflect certain rare conditions so that we can combine them with real X-rays to
have a sufficiently large database to train the neural networks to identify
these conditions in other X-rays."
Valaee is a member of the Machine
Intelligence in Medicine Lab (MIMLab), a group of physicians, scientists and
engineering researchers who are combining their expertise in image processing, artificial intelligence
and medicine to solve medical challenges. "AI has the potential to help in
a myriad of ways in the field of medicine," says Valaee. "But to do
this we need a lot of data—the thousands of labelled images we need to make
these systems work just don't exist for some rare conditions."
To create these artificial X-rays,
the team uses an AI technique called a deep convolutional generative
adversarial network (DCGAN) to
generate and continually improve the simulated images. GANs are a type of
algorithm made up of two networks: one that generates the images and the other
that tries to discriminate synthetic images from real images. The two networks
are trained to the point that the discriminator cannot differentiate real
images from synthesized ones. Once a sufficient number of artificial X-rays are
created, they are combined with real X-rays to train a deep convolutional
neural network, which then classifies the images as either normal or
identifies a number of conditions.
"We've been able to show that
artificial data generated by a deep convolutional GANs can be used to augment
real datasets," says Valaee. "This provides a greater quantity of
data for training and improves the performance of these systems in identifying
rare conditions."
Professor Shahrokh Valaee (ECE, at left) and PhD
candidate Hojjat Salehinejad are using machine learning to create simulated
chest X-ray images to train AI systems to identify rare pathologies. Credit:
Jessica MacInnis
The MIMLab compared the accuracy of their
augmented dataset to the original dataset when fed through their AI system and
found that classification accuracy improved by 20 per cent for common
conditions. For some rare conditions,
accuracy improved up to about 40 per cent—and because the synthesized X-rays
are not from real individuals the dataset
can be readily available to researchers outside the hospital premises without
violating privacy concerns.
"It's exciting because we've
been able to overcome a hurdle in applying artificial intelligence to medicine
by showing that these augmented datasets help to improve classification accuracy," says Valaee. "Deep
learning only works if the volume of training data is large enough and this is
one way to ensure we have neural networks that can classify images with high precision."
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